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Our lab uses multi-omic approaches to understand molecular mechanism of neurodegenerative diseases like Alzheimer’s disease and Fronto-temporal dementia (FTD). We use functional genomics approaches to better understand the role of distinct cell-types in disease pathophysiology to improve the design of therapeutic interventions for AD and FTD. Current transcriptomic approaches can powerfully investigate quantitative molecular phenotypes and pathways underlying disease progression in a genome-wide manner. Yet, they lack the specificity needed to comprehend the role of cell-type specific changes in disease pathophysiology. Our work will identify the molecular mechanisms underlying neurodegeneration and investigate how they differ from normal aging. Using single-cell multi-omic approaches coupled with bulk tissue sequencing, we hope to directly answer some of these questions.