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Our goal is to uncover the principles of immune regulation in the central nervous system (CNS) at organismal, cellular, and molecular levels. We study the cellular and molecular mechanisms of regulatory (Treg) cells during autoimmune neuroinflammation using Multiple Sclerosis (MS)-like disease model in mice. Our research intersects immunology, cell biology, physiology, and neuroscience. We use a combination of advanced multiphoton imaging, fate-mapped reporters, biophysical tools, and functional genetics in animal models to study spatiotemporal dynamics of Regulatory Immunity in CNS. Our studies illuminate the basic mechanisms of how Treg cells resolve neuroinflammation (CNS autoimmunity) and promote neuronal repair pathways (Remyelination). We aim to develop of Treg-cell therapy to achieve site-specific remyelination of denuded axons (e.g., MS) and lay the foundation for the CNS-tissue repair potential of Treg cells for other neurodegenerative diseases such as Alzheimer’s disease. In the long term, we seek to broaden our understanding of how neuroinflammation is regulated; this will guide the development of new therapeutic strategies for neuroinflammatory and autoimmune diseases of the CNS.