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The main goal of our lab is to understand the fundamental neural mechanisms underlying our ability to temporally organize our memories, as well as how this capacity is affected in cognitive disorders. Our primary approach is to train rats to perform complex sequence memory tasks (comparable to those used in humans) and then use high-density electrophysiological recordings techniques to examine how ensembles of neurons represent and compute the information needed to solve the task. Notably, unlike most rodent labs, we work in close collaboration with human fMRI labs to establish the cross-species correspondence of our research (at the behavioral and neural level). We also work in close collaboration with colleagues in Statistics to develop the analytical tools necessary to “decode” the information represented in the neural activity. At this time, we primarily focus on the fundamental function of the hippocampus and prefrontal cortex, as well as their functional interactions with associated structures, but are in the process of extending these approaches to study the neural mechanisms underlying memory impairments associated with aging, dementia, hypoxia, and radiotherapy.