Our project focuses on the development of highly efficient and reproducible brain organoid methods to investigate the origins of neural circuits and model neurodevelopmental disorders. We have contributed to set up cortical-subcortical fused-organoids to identify neural oscillations and establish a platform to examine interneuronopathy for neurodevelopmental disorders. Recently, we have worked on a project to determine the transcriptomic signatures of human pluripotent stem cells that predict efficient and reproducible cortical organoid formation. We have set out in our near future work to address three main aims: 1) create a powerful organ-on-a-chip systems to improve the established forebrain organoids, 2) develop brain organoid models for neurodevelopmental disorders, and 3) define the microcircuit properties of cortical organoids as a model system for human brain activities.