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Neurons in the neocortex are bombarded with thousands of inputs representing different senses, memories of past events or internal goals. The Neuronal Signal Integration Lab at UC Irvine aims to understand how individual cells and networks of neurons integrate the information arriving from these different modalities. We combine opto- and pharmacogenetic strategies with electrophysiology and optical recording methods to manipulate and monitor neuronal activity. These tools allow us to ask what neuronal signals underpin complex behaviors like decision-making, and how adverse environments disrupt these information streams, leading to impaired cognitive function. for more information: