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My lab studies the neurobiology and pharmacology of the endocannabinoids and other bioactive lipids. Our approach combines molecular and cellular biology, system biology and medicinal chemistry to discover transformative chemical probes that target lipid-signaling pathways. We were the first to elucidate pathways involved in the formation and deactivation of brain endocannabinoids, uncover important physiological functions of these compounds, and identify pharmacological agents that interfere with their deactivation. Agents discovered by my group have been broadly used by the scientific community and have inspired preclinical and clinical research in many labs of both academe and industry.